上腺瘤的女性化 - - 来自印度北部一家三级护理中心的病例系列
Prashant Hubballi1, Subhash Yadav1, Preeti Dabadghao1
1Department of Endocrinology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
Indian journal of endocrinology and metabolism
|September 8, 2025
概括
雌性化上腺瘤 (FATs) 很少见,通常是恶性上腺皮质癌 (ACC). 这项研究发现,即使在早期诊断,这些罕见的瘤的预后仍然很差.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
背景情况:
- 良性上腺瘤很常见,但分泌皮质醇,阿尔多或雌激素的功能性瘤较少发生.
- 混合激素分泌,特别是皮质醇和雄激素,引起对上腺皮质癌 (ACC) 的怀疑,这是一种罕见的恶性瘤.
- 雌激醇分泌的上腺瘤非常罕见,占所有上腺瘤的1-2%,并且往往是恶性的,预后不佳.
研究的目的:
- 研究女性化上腺瘤 (FATs) 患者的临床特征和结果.
- 为了突出与分泌雌二醇的上腺瘤相关的罕见性和诊断挑战.
主要方法:
- 从2013年1月到2023年12月进行了一项回顾性观察研究.
- 收集了来自医院信息系统的数据,用于患有上腺瘤和雌激醇水平升高的患者.
- 分析了四名雌醇水平升高的男性患者,其中两名患有ACC,两名患有良性瘤.
主要成果:
- 该研究确定了四名患有FAT的男性患者,平均年龄为45岁.
- 两名患者患有远程转移的ACC (韦斯评分6),而两名患者患有良性瘤.
- 所有患者都呈现出无痛的妇;三人有轻微的自主皮质醇分泌 (MACS).
- 瘤大小平均为10.7厘米,雌醇水平在显著范围内 (301-3648 pmol/L).
结论:
- 雌性化上腺瘤 (FATs) 很少见,主要是恶性 (ACC),并与可怕的预后有关.
- 尽管早期诊断和治疗,但ACC的短期生存率仍然很差.
- 这些发现强调了雌醇分泌上腺恶性瘤的攻击性和不良结果.
相关概念视频
01:17Anatomy of the Adrenal Glands
The adrenal or supra-renal glands, situated above the kidneys and aligned with the twelfth rib, are paired pyramid-shaped structures crucial for the body's stress response. During stress, these glands secrete hormones vital for adaptive physiological reactions.
These glands possess a distinctive yellow tinge due to the stored cholesterol and fatty acids required for hormone synthesis. They are encased in a fibrous capsule and cushioned by fat.
The adrenal gland comprises two distinct regions...
These glands possess a distinctive yellow tinge due to the stored cholesterol and fatty acids required for hormone synthesis. They are encased in a fibrous capsule and cushioned by fat.
The adrenal gland comprises two distinct regions...
01:31Hormones of the Adrenal Glands
Adrenal hormones play a pivotal role in maintaining the body's electrolyte balance and orchestrating responses to stress, showcasing the intricate functions of the adrenal cortex and medulla.
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and corticosterone...
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and corticosterone...
01:27Adrenal Gland Disorders
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
01:23Infertility in Males
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
01:28Infertility in Females
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of endometrial...
Endometriosis, a condition characterized by abnormal growth of endometrial...
01:26Cushing Syndrome I: Introduction
Cushing syndrome refers to the collection of clinical manifestations that arise when tissues are exposed to excessive amounts of cortisol or cortisol-like medications over an extended period. Cortisol, a glucocorticoid produced by the adrenal cortex, regulates metabolism, immune responses, and the body’s adaptation to stress. When its concentration remains chronically elevated, these physiological pathways become dysregulated, resulting in the characteristic features of the syndrome.Exogenous...