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早期儿童慢性病的神经发育结果:从病例对照研究的证据
Sahil Vikas1, Rajni Sharma1, Lokesh Saini2
1Department of Pediatrics, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Annals of neurosciences
|September 8, 2025
概括
儿童慢性病 (CKD) 显著影响神经认知发育,随着疾病的进展,结果会恶化. 早期干预对受影响的儿童至关重要.
科学领域:
- 儿科脏病学 儿科脏病学
- 神经发育儿科 神经发育儿科
- 儿童健康 儿童健康
背景情况:
- 患有慢性病 (CKD) 的儿童面临神经认知结果受损的风险.
- 童年早期大脑的快速发育使得这个时期对于评估CKD的影响至关重要.
研究的目的:
- 研究慢性病 (CKD) 对早期儿童神经认知的影响.
- 确定影响儿科CKD患者神经认知发育的与疾病相关的风险因素.
主要方法:
- 一项横截面病例控制研究涉及52名患有CKD (3-5期) 的儿童和52名年龄匹配的对照.
- 用印度婴儿发育评估尺度 (DASII) 评估神经认知结果.
- 进行统计分析以评估组之间的差异.
主要成果:
- 与对照人群相比,患有CKD的儿童在精神功能,运动功能和发育系数方面的得分明显较低.
- 神经认知功能随着CKD阶段的逐渐下降,而5期患者的得分最低.
- 在CKD不同阶段观察到体重,身高,头部周长和某些血液参数 (Hb,MCH,MCHC) 的显著差异.
结论:
- 慢性病 (CKD) 是一种严重的疾病,影响儿童的健康和发育.
- 神经认知结果的逐渐下降与晚期CKD相对应,对儿童整体发育产生负面影响.
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