肠道微生物群与结直肠癌中自-EMT动态的相互作用
Tiziana Vescovo1, Giulio Bontempi1,2, Mohammadreza Bayat1,3
1Department of Epidemiology, Preclinical Research and Advanced Diagnostics, National Institute for Infectious Diseases IRCCS "L. Spallanzani", Rome, Italy.
Frontiers in cell and developmental biology
|September 8, 2025
概括
肠道微生物群影响结肠直肠癌 (CRC) 的发展和治疗. 了解微生物转变为CRC诊断和治疗策略提供了新的途径.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
背景情况:
- 人类微生物群,特别是肠道中的微生物群,对宿主健康至关重要.
- 微生物失衡 (失生症) 越来越多地与结直肠癌 (CRC) 的发展和进展有关.
- 特定的细菌如 *Fusobacterium nucleatum* 和 *Escherichia coli* 促进CRC,而其他如 *Bifidobacterium* 和 *Lactobacillus* 提供保护.
研究的目的:
- 审查肠道微生物群和CRC之间的复杂关系.
- 突出微生物组成在CRC瘤发生和治疗反应中的作用.
- 讨论基于微生物群的诊断和治疗CRC的进展.
主要方法:
- 关于肠道微生物组和CRC的当前研究的文献综述.
- 对调查微生物对CRC炎症,基因毒性和细胞通路的影响的研究进行分析.
- 检查基于微生物群的新兴诊断生物标志物和治疗干预措施.
主要成果:
- 肠道失生症通过促进炎症,基因毒性压力和免疫逃避,促进CRC.
- 特定的微生物可以通过EMT和自干扰等机制驱动瘤发生.
- 有益的微生物增强免疫监测和肠道屏障功能,提供保护作用.
- 基于微生物群的生物标志物显示出早期CRC检测和患者分层的前景.
- 聚焦微生物群的疗法 (益生菌,益生菌,FMT,精密抗生素) 可以补充标准的CRC治疗.
结论:
- 肠道微生物群在CRC病变发生过程中起着重要作用,并影响治疗结果.
- 微生物组研究对于开发新型诊断工具和CRC个性化治疗策略至关重要.
- 进一步研究宿主微生物群相互作用对于推进CRC管理至关重要.
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