认知和全球形态测量轨迹作为青春的预测者 持续的痛苦的精神病般的经历
Nicole R Karcher1, Fanghong Dong1, Sarah E Paul2
1Department of Psychiatry, Washington University School of Medicine.
遗传和环境风险与恶化的精神病类经历 (PLEs) 有关. 认知和大脑结构的下降部分解释了青少年的这种联系.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 精神病学是一个精神病学.
背景情况:
- 青春期的精神病类似经历 (PLEs) 与遗传和环境风险因素有关.
- 这些经历可能与随着时间的推移,认知功能和大脑结构的变化有关.
研究的目的:
- 调查认知和全球形态测量指标的变化如何影响风险因素和持续痛苦的PLE之间的关系.
- 检查风险因素,认知/形态变化和青少年PLE之间的纵向关联.
主要方法:
- 利用了来自青少年大脑认知发展研究 (年龄9-13) 的三波纵向数据.
- 采用多组无变潜增长模型来分析认知指标和全球形态测量.
- 他们比较了三个组:持续的痛苦的PLE,暂时的痛苦的PLE和低级别的PLE.
主要成果:
- 患有持续令人痛苦的PLE的青少年随着时间的推移,认知和形态学表现出更急剧的下降.
- 认知和形态度指标的恶化部分介导了环境风险和持续痛苦的PLE之间的联系.
结论:
- 认知功能和大脑形态学的长度下降与青少年持续痛苦的PLE有关.
- 这些变化可能部分解释了环境风险如何导致令人痛苦的PLEs的发展.
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