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用奇托纳米颗粒封装的大麻提取物及其对抗皮肤病原体的抗菌潜力

Tomáš Skala¹, Jordi Ventura², Ángela Morellá-Aucejo^2,3,4

¹Department of Food Science, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, Prague, Czechia.

Frontiers in medicine

|September 8, 2025

概括

在奇多纳米颗粒中封装的大麻提取物显示出增强的抗菌性质和减少局部应用的细胞毒性. 这项创新改善了治疗皮肤感染的治疗方法,如皮肤植物病,并有助于伤口愈合.

科学领域:

制药科学制药科学
材料科学材料科学材料科学
皮肤病学皮肤病学

背景情况:

大麻化合物具有对治疗用途有价值的抗微生物特性.
大麻提取物的局部应用受到粘度,粘性和低生物利用度的限制.
基托桑纳米颗粒为增强局部药物输送提供了具有成本效益的解决方案.

研究的目的:

将不同菌株 (THCA-A,CBDA,CBGA) 的大麻提取物封装成基托桑纳米颗粒.
评估这些用于局部使用的纳米封装大麻提取物的抗菌和细胞毒性作用.
评估这种配方在治疗细菌感染和皮肤植物病方面的潜力.

主要方法:

大麻提取物是由Chocolope (THCA-A),Jonas 1 (CBDA) 和大麻G (CBGA) 菌株制备的.
提取物被封装成奇多纳米颗粒,使用不同的提取物:奇多比率.
进行了粒子表征,封装效率,抗菌活性 (MIC80) 和细胞毒性测试.

主要成果:

颗粒大小范围从89.1nm (空) 到355.6nm (大麻G提取物).
封装效率从44.65%到94.44%不等.
与纯提取物相比,封装的提取物显著改善了对*Nannizzia fulva*的抗菌活性,并降低了对人类角质细胞的细胞毒性.

结论:

基托桑纳米颗粒封装增强了大麻提取物的局部输送和疗效.
纳米配方降低了抗菌作用所需的提取物度,并降低了细胞毒性.
这种方法为皮肤植物病和伤口愈合提供了一个有前途的辅助治疗方法.

关键词:

它具有抗菌和抗真菌作用.大麻提取物大麻提取物封装的封装方式在纳米中,我们可以使用Nanochitosan.伤口愈合 - 伤口愈合

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