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Updated: Jan 18, 2026

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism
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酸结合二胺酸morpholino oligonucleotides的分子特性和分子内相互作用

Evgenii Kliuchnikov1, Farkhad Maksudov1, Daniel Pierson2

  • 1Department of Chemistry, University of Massachusetts, Lowell, MA 01854, USA.

Molecular therapy. Nucleic acids
|September 8, 2025
PubMed
概括

合酸胺酸甲醇核酸 (PPMOs) 形成独特的结构,增强细胞吸收,而不改变核心酸胺酸甲醇核酸 (PMO) 的特性.

关键词:
杜申尼肌肉发育不良症是什么模拟MDMD的模拟MT:寡核酸:治疗方法和应用.一个圆形的二重化.计算分子建模计算分子建模解决方案结构的整体.提供寡核酸的输送.二胺酸 二胺酸 二胺酸 二胺酸 二胺酸 二胺酸粘度与度概况的比较

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Phosphodiester bond forms when a phosphoric acid molecule (H3PO4) links with two hydroxyl groups (–OH) of two other molecules, forming two ester bonds. Two water molecules are released in this process. The phosphodiester bond is commonly found in nucleic acids (DNA and RNA) and plays a critical role in their structure and function.
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Nucleic Acid Structure

The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
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