在健康成年人中补充二甲糖酸盐报告睡眠不足:一个随机的,安慰剂控制的试验
Julius Schuster1, Igor Cycelskij1, Adrian Lopresti2
1Institute of Food and One Health, Leibniz University Hannover, Hanover, Lower Saxony, Germany.
Nature and science of sleep
|September 8, 2025
概括
在睡眠质量差的成年人中,补充二糖酸盐适度改善了失眠症状. 这表明,睡眠困难的个体,特别是那些饮食摄入量较低的人,可能会受益.
科学领域:
- 营养神经科学 营养神经科学
- 睡眠医学 睡眠医学
- 临床试验 临床试验
背景情况:
- 睡眠质量差是影响整体健康和福祉的一个普遍问题.
- ,特别是双甘酸盐的形式,正在研究其潜在的促进睡眠的特性.
- 现有研究表明,水平与睡眠调节之间可能存在联系.
研究的目的:
- 为了评估二糖酸盐补充剂在减轻健康成年人睡眠质量不佳的健康成年人失眠症状方面的疗效.
- 量化每日二糖酸对睡眠质量指标的影响.
- 探索可能从补充中获得更大的好处的潜在子组.
主要方法:
- 一项随机,双盲,安慰剂对照试验,涉及155名睡眠质量差的成年人 (18-65岁).
- 参与者每天接受250毫克元素二糖酸盐或安慰剂.
- 在基线和随访点使用失眠严重程度指数 (ISI) 和其他心理问卷来评估睡眠质量.
主要成果:
- 在4周内,二甲酸盐组与安慰剂组相比,在失眠严重性指数 (ISI) 得分上呈现出统计学上显著的较大降低 (p=0.049).
- 观察到一个小效应大小 (科恩d=0.2),表明不眠症严重程度的适度但显著改善.
- 探索性分析表明,基线较低的摄入量较低的个体经历了更实质性的改善,暗示了高响应者的子组.
结论:
- 补充二糖酸盐在改善睡眠质量差的成年人失眠的严重程度方面提供了适度的好处.
- 需要进一步的研究以客观的睡眠测量和更长的干预期来证实这些发现.
- 建议对饮食中的摄入量和状态进行系统评估,以便在未来的研究中确定潜在的高响应者.
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