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Updated: Jan 18, 2026

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Closure of a Patent Foramen Ovale PFO: An Intervention Sequence
Published on: December 23, 2022
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对于密码性中风和与年龄有关的差异而言,形孔直径的预测值
Rui Wang1, Miao Qiao1, Guanghui Song1
1Department of Ultrasound Imaging, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Frontiers in cardiovascular medicine
|September 8, 2025
概括
专利卵孔 (PFO) 增加了密码性中风 (CS) 的风险,特别是在更大的直径的情况下. 风险因素因年龄而异,PFO解剖学在年轻患者中至关重要,而像吸烟这样的系统因素在老年人中具有重要意义.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 卵孔 (PFO) 是一种常见的心脏异常,与密码性中风 (CS) 有关.
- 现有的PFO相关的CS风险分层工具存在局限性,特别是在老年人群中.
- 了解特定年龄的风险因素对于有效预防PFO患者中风至关重要.
研究的目的:
- 在患有 patent foramen ovale (PFO) 的患者中识别密码性中风 (CS) 的独立风险因素.
- 评估年龄相关的年轻和老年PFO患者之间的风险因素差异.
- 评估PFO直径的预测值和CS的其他因素.
主要方法:
- 对344名PFO患者的回顾性分析,分为没有中风,CS和非密码性中风组.
- 收集人口统计,临床,实验室和详细的PFO解剖数据.
- 多变量后勤回归和接收器运行特征 (ROC) 曲线分析以确定风险因素和最佳截止值.
主要成果:
- 17.2%的PFO患者经历了CS,更大的PFO直径是一个独立的风险因素 (最佳切断值1.75毫米).
- 升高的白细胞计数,大右向左的分流,以前的中风/TIA和皮质梗塞与CS相关.
- 在年轻患者 (<60岁) 中,PFO直径和分流体大小是关键因素,而在老年患者 (≥60岁) 中,PFO直径,分流体大小和吸烟是显著的.
结论:
- 扩大的PFO直径是CS的显著解剖风险因素.
- 在PFO患者中,CS的危险因素概况因年龄而异.
- 考虑PFO解剖学和系统因素的综合评估对于PFO患者中风风险分层至关重要,特别是在老年人中.
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