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Ultrasonography

Ultrasonography

Ultrasonography is an imaging technique that uses high-frequency sound waves to visualize the body's internal structures. It is a non-invasive and safe procedure that does not involve the use of ionizing radiation, making it widely used in various medical fields. Ultrasonography is used to study heart function, blood flow in the neck or extremities, certain conditions such as gallbladder disease, and fetal growth and development.
During an ultrasonography procedure, a handheld device called...

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Updated: Jan 18, 2026

Wideband Optical Detector of Ultrasound for Medical Imaging Applications

Wideband Optical Detector of Ultrasound for Medical Imaging Applications

Published on: May 11, 2014

超声波成像和机器学习用于生物反应器中的非破坏性传感.

Mary Serpe¹, Caleb Lee¹, Reid Povinelli¹

¹Department of Engineering, Boston College, 245 Beacon Street, Chestnut Hill, Massachusetts 02446, United States.

|September 8, 2025

概括

超声波成像提供了一种非侵入性方法来监测细胞在细胞农业中的细胞生长. 这项技术可以评估植物支架,确保大规模细胞生产的质量控制,而不会损坏样品.

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科学领域:

生物技术是生物技术.
细胞农业细胞农业
生物医学工程生物医学工程

背景情况:

细胞疗法和细胞农业需要可扩展的,非侵入性的监测方法.
生物反应器需要强大的质量控制,以有效地生产细胞.
目前的监测技术可能是侵入性的或昂贵的.

研究的目的:

研究超声波技术,以鉴定植物性支架中的细胞生长和脱细胞化.
评估使用超声波作为细胞农业中的非破坏性质量控制工具的可行性.

主要方法:

在新鲜的菜叶,脱细胞化的叶子和种子的支架上进行了超声波成像.
机器学习算法用于图像细分和分析.
统计分析比较了样本类型之间的像素强度差异.
组织学分析作为验证方法.

主要成果:

在新鲜和脱细胞的菜叶之间观察到平均像素强度的显著差异 (p < 0.001).
在带有和没有种子细胞的脱细胞区域之间检测到明显的强度变化 (p = 0.001).
组织学分析证实了超声波的发现.

结论:

超声波成像显示,它是一个可行的,非破坏性的工具,用于评估细胞农业中的植物支架.
这种方法可以帮助在大规模的细胞生产过程中进行质量评估.
超声波为监测细胞生长和支架完整性提供了一种经济有效和高效的替代方案.