瘤微环境和肝细胞癌免疫治疗策略的进展
Jiahao Xue1, Jingchang Zhang2, Gang Chen3
1Department of Biliary-Pancreatic Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.
Oncology research
|September 8, 2025
概括
肝细胞癌 (HCC) 治疗面临着免疫抑制瘤微环境 (TME) 的挑战. 组合免疫疗法在克服耐药性和改善HCC患者的治疗结果方面表现有前途.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 癌症研究 癌症研究
背景情况:
- 肝细胞癌 (HCC) 是一种具有侵略性的癌症,其特点是免疫抑制性瘤微环境 (TME).
- 这种TME促进瘤生长,免疫逃避和治疗抵抗.
- 由于这些免疫抑制因素,当前的免疫疗法,如免疫检查点抑制剂 (ICI),具有低于最佳的疗效.
研究的目的:
- 审查TME和HCC中的免疫治疗反应之间的复杂相互作用.
- 突出结合策略如何克服HCC的免疫抵抗.
- 讨论未来改善HCC治疗结果的方向.
主要方法:
- 对目前关于HCC,TME和免疫治疗的研究进行文献综述.
- 分析组合策略,包括双重检查点封锁和ICI与其他代理商的协同使用.
- 讨论与TME相关的生物标志物和个性化治疗方法.
主要成果:
- 含有诸如瘤相关巨细胞,调节性T细胞 (Tregs) 和骨髓系衍生抑制细胞 (MDSCs) 等成分的TME显著阻碍了抗瘤免疫力.
- 组合疗法,如双检查点阻塞 (针对PD-1,PD-L1,CTLA-4) 和ICI与抗血管原或TME向药物的组合,显示出增强免疫功效的潜力.
- 这些综合方法在克服HCC治疗耐药性方面表现有前途.
结论:
- 组合免疫疗法是一种有希望的策略,通过调节免疫抑制TME来提高HCC的治疗疗效.
- 解决治疗耐药性和与免疫相关的不良事件对于推进组合疗法至关重要.
- 未来的研究应该集中在与TME相关的生物标志物和个性化治疗策略上,以优化HCC患者的治疗结果.
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