在衰老的背景下,膀癌的表观遗传调节
Xuewei Liu1, Guofeng Ding2, Yifan Liu3
1Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China.
Frontiers in pharmacology
|September 8, 2025
概括
衰老加剧了膀癌 (BC) 通过表观遗传变化,如DNA甲基化变化和改变的非编码RNA表达. 这些表观遗传修饰促进了老年人瘤生长和治疗耐药性.
科学领域:
- 在瘤学瘤学.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 衰老研究研究 衰老研究
背景情况:
- 膀癌 (BC) 主要影响老年人,衰老有助于其发病和进展.
- 与年龄相关的因素,如免疫衰老,炎症和基因组不稳定性,创造了一个有利于瘤的环境.
- 表观遗传变化,包括DNA甲基化,染色质修饰突变和非编码RNA失调,是BC的关键驱动因素,特别是在老年患者中.
研究的目的:
- 审查衰老和相关表观遗传变化的关键作用在膀癌的发展和进展.
- 为了突出在BC病变发生过程中DNA甲基化的双重功能.
- 探索表观遗传变化对老年人瘤攻击性,免疫逃避和治疗耐药性的影响.
主要方法:
- 文献综述专注于衰老,表观遗传学和膀癌之间的相互作用.
- 分析分子机制,包括DNA甲基化,基因素修饰和BC中的非编码RNA失调.
- 检查与年龄相关的表观遗传过程的变化及其对癌症风险和进展的影响.
主要成果:
- 衰老通过免疫和炎症促进了亲瘤原生环境,增加了BC风险.
- 全球低甲基化和瘤抑制基因 (例如CDKN2A) 的焦点高甲基化在BC中至关重要,特别是在较旧的组织中.
- 染色质修饰剂的突变和改变的基因组修饰酶 (例如,EZH2) 促进免疫逃避和攻击性.
- 失调的microRNAs (miRNAs) 和长非编码RNAs (lncRNAs) 有助于增殖,转移和免疫抑制,老化加剧了miRNA处理.
- 老年患者累积的表观遗传变化促进了瘤的进展和治疗耐药性.
结论:
- 表观遗传变化是膀癌的发展和老年人的进展的核心.
- 表观遗传生物标志物显示出早期检测和BC风险分层的潜力.
- 表观遗传疗法 (DNMTi,EZH2i,HDACi) 为恢复瘤抑制功能和增强免疫原性提供了有希望的策略,以改善老年人BC结局.
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