在类风湿性关节炎相关的间歇性肺部疾病实用性比较有效性试验:一个多视角的定性研究
Angela Kaczorowski-Worthley1, Dinesh Pal Mudaranthakam2, Janell Reichuber3
1University of Kansas School of Medicine, Kansas City, KS.
CHEST pulmonary
|September 8, 2025
概括
专家和患有类风湿性关节炎相关间歇性肺病 (RA-ILD) 的患者支持使用现实世界和患者报告结果的实用试验. 这种方法可以降低成本,并改善RA-ILD的以患者为中心的研究.
科学领域:
- 类风湿病学 类风湿病学
- 肺部病理学 肺部病理学
- 临床试验设计 临床试验设计
背景情况:
- 类风湿性关节炎相关的间歇性肺病 (RA-ILD) 预后不佳,治疗选择有限,当前免疫调节和抗纤维素策略的有效性不确定.
- 开发RA-ILD的有效临床试验是具有挑战性的,因为成本高,需要患者和专家对可行性和设备的投入.
研究的目的:
- 探讨RA-ILD专家和患者关于RA-ILD的设备,可行性和最佳试验设计的观点.
- 确定在RA-ILD中开发以患者为中心的临床试验的关键考虑因素.
主要方法:
- 进行了一项定性研究,涉及10名RA-ILD专家和29名患有间歇性肺病 (或他们的护理人员) 的患者,分别来自3个患者小组.
- 讨论被转录和分析,使用归纳编码来开发一个专题网络.
主要成果:
- 专家强调了治疗策略的可变性,患者报告结果的重要性,以及在试验设计中平衡实用主义与数据收集.
- 患者强调了关键的结果,参与障碍,以及以患者为中心的研究方法的必要性.
结论:
- 在RA-ILD试验中,专家和患者组都偏爱现实世界的临床结果和患者报告的结果作为主要终点.
- 实用性试验设计被视为一个可行的策略,以降低成本,扩大资格,并加强以患者为中心的研究在RA-ILD.
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