探索多维贫困和抗生素耐药性之间的关联:来自巴基斯坦混合方法研究的发现
Iltaf Hussain1,2,3, Muhammad Fawad Rasool4, Jamshid Ullah5
1Department of Pharmacy Administration, School of Pharmacy, Xi'an Jiaotong University, Xi'an, China.
The Lancet regional health. Southeast Asia
|September 8, 2025
概括
贫困显著增加了尿路感染中多药耐药性 (MDR) 的风险. 结构性障碍,如卫生条件不佳和医疗保健接入,加剧了这种联系,凸显了公平干预的必要性.
科学领域:
- 全球健康 全球健康
- 传染性疾病 传染性疾病
- 健康的社会经济决定因素
背景情况:
- 越来越多的人认为贫困是影响抗生素耐药性的因素.
- 与贫困相关的社会不平等可能在塑造抗生素耐药性模式方面发挥关键作用.
- 以前的研究还没有充分探讨贫困和抗生素耐药性之间的多方面的关系.
研究的目的:
- 评估多维贫困在抗生素耐药性发展中的作用.
- 研究尿路感染患者贫困程度与抗生素耐药性之间的关联.
主要方法:
- 在巴基斯坦进行了一项混合方法研究,涉及698名尿路感染患者.
- 多维贫困指数 (MPI) 衡量了贫困;抗生素耐药性数据来自易感性报告.
- 调查加权后勤回归和定性访谈分析了MPI,抗生素耐药性和水,卫生和卫生 (WASH) 等相关因素之间的关联.
主要成果:
- 多维贫困独立地与多药耐药性 (MDR) 的可能性增加有关.
- 较高的贫困水平与明显增加的MDR风险相关,即使经过对抗生素滥用和不良WASH实践进行调整.
- 定性数据揭示了导致自我治疗和不遵守的财务障碍,以及导致感染传播的糟糕的WASH.
结论:
- 贫困程度的增加与抗生素耐药性风险的增加有关.
- 结构性障碍,而不仅仅是个人选择,有助于贫困人口的抗生素耐药性.
- 干预措施必须解决医疗保健不平等问题,改善WASH,规范抗生素获取,并促进行为改变.
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