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在采样策略和测量扩散交换模型上,使用双扩散编码序列测量扩散交换

Alfredo Ordinola¹, Shan Cai^2,3, Peter Lundberg^2,3

¹Department of Biomedical Engineering (IMT), Linköping University, Linköping, S-58185, Sweden.

Magnetic resonance letters

|September 8, 2025

概括

扩散磁共振成像 (dMRI) 现在可以更好地描述使用双扩散编码 (DDE) 和新型采样方案的水交换. 几乎均和对角取样方法在估计样本区间之间的水流动时显示出更高的准确性.

科学领域:

医疗成像医学成像
生物物理学的生物物理.
量化MRI是指数量化的MRI.

背景情况:

生物区间之间的水交换对于理解组织功能至关重要.
扩散磁共振成像 (dMRI) 提供了一种非侵入性方法来研究这种交流.
现有的dMRI模型通常依赖于双扩散编码 (DDE) 信号的特定子集.

研究的目的:

在一般的DDE信号表示中评估不同的采样方案,以描述水交换.
将拟议的抽样方案的表现与既有模型及其部分抽样策略进行比较.
评估使用通用DDE信号与可变采样进行交换测量的可行性.

主要方法:

采用了DDE信号的总体表示形式,采用常数b1,对角和反对角采样方案.
提出并将近乎统一的抽样方案与现有方法进行比较.
应用过器交换和快速交换模型及其各自的亚抽样方案.
经过验证的方法使用模拟和实验数据从一个桌面MRI扫描仪.

主要成果:

在合成数据上,对角和近均的采样方案提供了与地面真相相一致的估计.
在实验数据上,与全空间估计相比,偏移的对角线和近均的方案产生了最一致的结果.
拟议的采样方案在估计水交换方面表现强.

结论:

使用可变采样方案的一般DDE信号表示法测量水交换是可行的.
几乎均的和对角的采样策略显示出在dMRI中准确的交换估计的前景.
未来的工作重点应该是优化采样方案,并将额外的生物物理特性纳入交换模型.

关键词:

扩散式核磁共振成像 (MRI)双扩散编码是双扩散编码.抽样计划抽样计划交换水交换水交换水

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