在自闭症谱系障碍中,25 (OH) D2,25 (OH) D3和核心症状之间的关系
Liu Jia1, Du Hongfei2, Zhao Deyun1
1Department of Pharmacy, Children's Hospital of Hebei Province, Shijiazhuang, Hebei, China.
Frontiers in pediatrics
|September 8, 2025
概括
患有自闭症谱系障碍 (ASD) 的儿童的维生素D水平较低,特别是25(OH) D2和25(OH) D3. 较低的维生素D3水平与更严重的自闭症症状相关,并影响发展.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 神经发育障碍 神经发育障碍
- 营养科学 营养科学
背景情况:
- 自闭症谱系障碍 (ASD) 是一种复杂的神经发育状况.
- 维生素D在各种身体功能中起着至关重要的作用,包括大脑发育.
- 改变维生素D水平与ASD病理生理学有关.
研究的目的:
- 在被诊断患有自闭症的儿童中检查血清中25(OH) D2和25(OH) D3的水平.
- 分析这些维生素D代谢物与ASD核心症状之间的相关性.
- 检查维生素D水平与ASD儿童发育结果之间的关系.
主要方法:
- 一项病例控制研究,涉及208名患有自闭症儿童和208名健康对照.
- 使用高性能液体染色体协同质谱法 (HPLC-MS/MS) 量化血清25(OH) D2和25(OH) D3水平.
- 用自闭症行为检查表 (ABC) 和儿童自闭症评分表 (CARS) 评估ASD症状.
- 儿童的发育被用盖塞尔发育表 (GDS) 来评估.
主要成果:
- 与对照人群相比,患有自闭症儿童的血清含量显著降低了25[OH]D2和25[OH]D3的水平.
- 较低的血清25(OH) D3水平与ASD症状的严重程度增加有关.
- 血清25(OH) D2水平与较低的适应性行为和个人社会技能有显著的相关性.
- 较高的血清25(OH) D3水平与更好的适应性行为,精细运动技能和个人社会发展有关.
结论:
- 与健康同龄人相比,患有自闭症的儿童表现出25[OH]D2和25[OH]D3的缺陷.
- 确定了维生素D异型在自闭症中的不同作用:25(OH) D2影响适应性和个人-社会行为,而25(OH) D3与症状严重程度相反相关,并与发展里程碑积极相关.
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