第四阶段前列腺癌管理策略的比较有效性:叙述性审查
Okelue E Okobi1,2, Tobechukwu J Okobi3, Francis Okobi4
1Family Medicine, Larkin Community Hospital Palm Springs Campus, Miami, USA.
Cureus
|September 8, 2025
概括
第四期前列腺癌的治疗已经演变为组合疗法,包括使用新药或化疗的雌激素剥夺疗法 (ADT),改善生存率. 息性放射治疗有助于控制转移性前列腺癌患者的症状.
科学领域:
- 在瘤学瘤学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 第四阶段的前列腺癌 (PCa) 表示超出前列腺的转移性疾病.
- 目前的指导方针强调了已确认转移性传播的息管理.
- 治疗已经从雄激素剥夺疗法 (ADT) 单一疗法转向强化组合疗法.
研究的目的:
- 为了评估ADT,化疗,新兴激素药物和 IV 阶段的息性放射治疗的比较有效性,PCa.
- 审查目前转移性前列腺癌的治疗模式.
主要方法:
- 在PubMed,Embase和Cochrane图书馆的结构化文献搜索 (2015年1月 - 2025年5月).
- 包括对接受全身疗法或放射治疗的IV期PCa的成年男性进行英语研究.
- 不包括临床前研究,病例报告和非转移性人群.
主要成果:
- ADT是转移性疾病的基础.
- 结合治疗 (例如,恩扎胺,阿比拉) 与ADT改善了高风险荷尔蒙敏感患者的无进展生存 (PFS) 和整体生存 (OS).
- 在高体积的转移性激素敏感性疾病中,多西塔克塞尔提供生存益处;卡巴西塔克塞尔是抵抗割的环境的选择.
结论:
- 第四阶段的PCa管理需要个性化,以息为重点的策略.
- 早期的组合方法,考虑到疾病的数量,表现状况,并发症和偏好,是有价值的.
- ADT是基石,系统强化和放射治疗提供了附加的好处.
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