在雄性小鼠中,依赖时间的皮质反应对午睡中断的反应
Jingwei Ding1, Shigenobu Shibata1,2, Tatsuhiko Kubo1
1Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Frontiers in neuroscience
|September 8, 2025
概括
扰乱白天小睡会增加体温和活动,但对晚些时候的睡眠或压力标志物的影响很小. 皮层基因表达表现出时间依赖的变化,有早期应激反应和晚期神经元结构调整.
科学领域:
- 时间生物学 时间生物学
- 睡眠科学 睡眠科学
- 神经科学是一个神经科学.
背景情况:
- 白天小睡 (siestas) 对于缓解睡眠压力和生理平衡至关重要.
- 午睡中断对生理和分子过程的影响尚不清楚.
研究的目的:
- 为了研究午睡中断对压力,睡眠,行为和前额叶皮层基因表达的影响.
- 了解依赖于时间的分子适应性,对午睡中断的理解.
主要方法:
- 午睡期 (ZT20-23) 通过床单更换每天被打断两周.
- 评估核心体温,运动活动,清醒,睡眠结构,行为和血清压力标志物.
- 在ZT0和ZT12进行了额叶皮层的转录基因分析.
主要成果:
- 午睡中断增加了核心体温,运动活动和清醒.
- 观察到对轻相睡眠,行为或血清压力标志物的最小影响.
- 转录组分析揭示了时间依赖的反应:ZT0显示激活的压力/恒常路径,而ZT12突出显示了神经元结构和运输的基因.
结论:
- 短期的午睡中断会导致特定阶段的皮质适应.
- 这些适应包括早期应激缓解 (ZT0) 和后来的突触重塑 (ZT12).
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