一个多模态观察案例对照研究,探讨从普通人群中高阳性精神分裂症个体的肠道微生物群-海马体变化
Galya C Iseli1,2,3, Jorge F Vázquez-Castellanos4,5, David Coynel2,3
1University of Basel, Department of Clinical Research (DKF), University Psychiatric Clinics, Translational Neurosciences, Basel, Switzerland.
Biological psychiatry global open science
|September 8, 2025
概括
改变的肠道微生物可能与高精神分裂型个体的海马体变化有关. 这表明,对于影响海马体的精神病相关症状,潜在的微生物干预措施.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 精神病学是一个精神病学.
背景情况:
- 海马在精神病中至关重要,显示体积减少和新陈代谢改变 (输血,谷氨酸/GABA失衡).
- 肠道微生物群的组成影响大脑新陈代谢,但其在精神病中的海马体变化中的作用尚不清楚.
研究的目的:
- 为了研究肠道微生物群,海马体结构/代谢和健康成年人的精神分裂之间的关系.
- 探索肠道微生物组组成和高精神分裂型个体的海马体变化之间的潜在联系.
主要方法:
- 在142名健康参与者 (69名高精神分裂型,72名低精神分裂型) 的横截面研究.
- 利用临床/认知测试,用于肠道微生物群的16SrRNA基因测序,以及用于海马分析的多式神经成像 (MRI,ASL,MRS).
主要成果:
- 在多次比较纠正后,认知,神经成像或微生物组组成没有显著的群体差异.
- 在高精神分裂型组中,谷氨酸和GABA比率与社会退缩相关.
- 在整个样本中,肠道微生物肠道类型之间,海马子场体积和谷氨酸/GABA水平显著不同.
结论:
- 研究结果表明,肠道微生物组成和海马体变化之间存在潜在的联系,这些变化发生在阳性精神分裂型的个体中.
- 结果支持进一步研究精神病中的肠-大脑相互作用,并开发针对海马功能的微生物干预措施.
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