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在深度大脑刺激中出现周周:常见的并发症还是罕见的挑战?
Martin Nevrly1, Filip Blazek2, David Krahulik2
1Department of Neurology, University Hospital and Faculty of Medicine and Dentistry, Palacký University, Olomouc, Czechia.
Frontiers in surgery
|September 8, 2025
概括
在深度大脑刺激 (DBS) 后出现症状的周围 (PLE) 是罕见的,但可治疗的. 皮质类固醇治疗有效地消除了,使得在患有运动障碍的患者中能够成功地继续DBS治疗.
科学领域:
- 神经外科 神经外科
- 神经学 神经学
- 医疗成像医学成像
背景情况:
- 周周 (PLE) 是深度大脑刺激 (DBS) 的已知并发症.
- 虽然通常无症状,但严重的PLE可能会导致神经症状,影响患者的结果.
- 这项研究侧重于DBS患者的症状性PLE.
研究的目的:
- 为了分析症状性PLE在接受DBS治疗运动障碍的患者中的表现和管理.
- 评估对症状性PLE的皮质类固醇治疗的有效性.
- 评估PLE对延续DBS治疗的影响.
主要方法:
- 对接受DBS的191名患者进行了回顾性审查.
- 通过术后成像和临床随访,识别和评估症状性PLE病例.
- 用皮质类固醇治疗症状性PLE,通过成像和神经评估进行监测.
主要成果:
- 五名患者 (2.6%) 发展出症状性PLE,表现为认知能力下降和运动障碍.
- 手术后出现了几周到几个月的症状.
- 皮质类固醇治疗导致所有病例的临床改善和水解决,使得成功重新启动DBS治疗.
结论:
- 症状性PLE是一种罕见但显著的DBS并发症.
- 早期检测和及时的皮质类固醇管理对于症状缓解和持续的DBS治疗至关重要.
- 进一步的研究和警的术后监测对于改善PLE管理至关重要.
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