一种含有非自然氨基酸的两性作为RDC测量调整介质

Yishen Wang1, Haizhi Yin1, Yanling Yang1

  • 1School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan, 430074, China.

Magnetic resonance letters
|September 8, 2025
PubMed
概括

类蛋白作为NMR的对齐介质,使分子结构的确定成为可能. 一种新型的自我组装介质改善了NMR光谱的质量,并有助于定义天然产品的配置.

相关概念视频

pH01:24

pH

The potential of hydrogen (pH) is a measure of the acidity or basicity of a water-based solution determined by the concentration of hydronium ions (H3O+). In one liter of pure water at neutral pH, there are 1×10−7 moles of hydronium ions. However, the extensive range of hydronium ion concentrations present in water-based solutions makes measuring pH in moles cumbersome. Therefore, a pH scale was developed to convert moles of hydronium ions into the negative logarithm of the hydronium ion...
Chemical Shift: Internal References and Solvent Effects01:17

Chemical Shift: Internal References and Solvent Effects

In an NMR sample, precise measurement of the absolute absorption frequencies of nuclei is difficult. A standard internal reference compound is added, and the frequency difference between the reference signal and sample signals is measured.
The internal reference compound generally used in NMR spectroscopy is tetramethylsilane (TMS). TMS is preferred because it is chemically inert, soluble in NMR solvents, and easily removable. Also, the highly shielded methyl protons in TMS yield an intense...
Measurement of Air Content in Concrete01:23

Measurement of Air Content in Concrete

Air content measurement in concrete is critical for ensuring structural integrity and durability of concrete structures, especially in environments prone to severe weather conditions. Accurate air content analysis optimizes concrete's resistance to freeze-thaw cycles and enhances its workability and strength. Several methods are standardized under ASTM guidelines to measure the air content in fresh concrete, each suitable for different concrete types and conditions.
The pressure method,...