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地理缩治疗的真实世界经验用Avacincaptad Pegol治疗

Abdullah Abou-Samra^1,2, Muhi Dean Barazi^1,3, Amira Abbas²

¹Retina Group of Washington, Reston, VA, USA.

Journal of vitreoretinal diseases

|September 8, 2025

概括

实际数据显示,avacincincaptad pegol (一种治疗地理缩的药物) 具有普遍有利的安全性. 副作用不常见,眼内压升高和转化为新血管AMD的比例较低.

科学领域:

眼科医生眼科眼科
视网膜疾病视网膜疾病
药物监督药物监督药物监督

背景情况:

地理缩 (GA) 是一种与年龄相关的黄斑变性 (AMD) 的高级形式.
阿瓦辛卡普塔德 (Avacincaptad pegol) 是一种用于GA的新型治疗剂.
现实世界的安全数据对于了解治疗风险至关重要.

研究的目的:

为了评估avacincaptad pegol在GA患者的大队伍中的真实世界的安全性和临床经验.
为了确定与avacincaptad pegol治疗相关的不良事件.

主要方法:

追溯性,观察性队列研究.
从PRISM愿景组采集的数据,使用avacincaptad pegol (2023年8月至2024年10月) 的J代码.
包括335名患者的461只眼睛,这些患者接受了静脉内avacincaptad pegol 2 mg的治疗.

主要成果:

平均随访时间:120天;平均注射间隔:52天.
14只眼睛 (3%) 经历了急性眼内压力升高;没有报告的内眼炎或视神经病变.
8只眼睛 (2.03%) 转化为新血管性AMD;1只眼睛 (0.2%) 有玻璃体出血.

结论:

在真实世界GA治疗中,Avacincaptad pegol显示出可管理的安全性.
这些发现支持临床医生评估这种GA治疗不良事件的风险.
对于这种新兴的治疗方法,进一步监测是必不可少的.

关键词:

与年龄相关的黄斑变性.没有人抓住了佩戈尔的手.补充抑制是补充的抑制.地理缩是地理上的缩.眼内炎症是一种眼内炎症.在安全方面,安全是安全的.血管炎是一种血管炎.

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