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Updated: Jun 21, 2026

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Tagraxofusp,一种针对CD123的治疗方法,用于慢性髓性单细胞白血病:一期半研究的最终结果

Mrinal M Patnaik1, Haris Ali2, Eunice S Wang3

  • 1Division of Hematology, Mayo Clinic, Rochester, MN.

Blood neoplasia
|September 8, 2025
PubMed
概括

作为一种针对CD123的治疗方法,Tagraxofusp在慢性骨髓单细胞白血病 (CMML) 患者中显示出可管理的安全性. 然而,该治疗显示出有限的临床疗效,没有观察到完全或部分反应.

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Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...