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设计,合成和生物评估8-Phenyl-THIQ作为抗抑郁药剂

Xiaopeng Wei1, Fan Yang1, Nuo Xu1

  • 1Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin, P. R. China.

Drug development research
|September 8, 2025
PubMed
概括

研究人员合成了magnoflorine的新型8-phenyl tetrahydroisoquinoline (8-phenyl-THIQ) 类似物,用于治疗抑郁症. 化合物1e和1j显示出显著的抗抑郁活性,良好的合成和有利的ADME/T特性.

关键词:
抑郁 抑郁症 抑郁症 抑郁症 抑郁症马格诺佛洛林 (MAG) 是一种神经保护性神经保护剂结构的修改,结构的改变.四化化素 (THIQ) 的使用.

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