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在泰国人群中,氨酸S-甲基转移酶 (TPMT) 活动切断值

Pimonpan Jinda¹, Pimpun Kitpoka², Wimol Thienphopirak²

¹Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Annals of clinical biochemistry

|September 8, 2025

概括

这项研究确定了针对个性化硫氨酸药物治疗的关键的硫氨酸S-甲基转移酶 (TPMT) 活性切断值. 确定这些值有助于预测患者的反应,并最大限度地减少药物不良反应.

科学领域:

药物遗传学药物遗传学
临床酶学临床酶学
药物代谢药物代谢

背景情况:

氨酸S-甲基转移酶 (TPMT) 对于代谢氨酸药物至关重要.
在TPMT活动的变化可以导致药物的疗效和毒性改变.
确定特定人群的切割值对于安全的氨酸治疗至关重要.

研究的目的:

确定泰国健康人口中TPMT活性的参考范围和临床适用的切线值.
为了区分正常,减少或缺陷TPMT活动的个体.
为了支持个性化医疗方法在提奥普林药物治疗.

主要方法:

招募了457名健康参与者 (207名儿童,250名成年人) 没有先前暴露于氨酸.
测量了TPMT活动和基因型的常见缺陷变体 (TPMT*3A, *3B, *3C).
使用接收机运行特征 (ROC) 曲线分析来确定最佳切断值.

主要成果:

根据基因型 (野生型,异合体,复合异合体) 定义了儿童和成人特定的TPMT活动切线值.
在儿童和成人队列中区分TPMT活动水平方面获得了高灵敏度和特异性.
儿童 (野生类型的≥52.9nmol6-MMP/g Hb/h) 和成年人 (野生类型的≥44.6nmol6-MMP/g Hb/h) 报告了不同的截止值.

结论:

建立了特定于人群的TPMT活性截止值,对于管理氨酸治疗至关重要,特别是在泰国.
这些确定的值促进了个性化治疗策略,降低了药物不良反应的风险.
强调TPMT活动截止值的本地验证的重要性,因为人口间的变化.

关键词:

6 - 默卡普托氨酸是什么?药物基因组学药物基因组学在ROC曲线上,ROC曲线一个成熟的成年人.孩子孩子孩子孩子孩子孩子截止时间截止时间与药物相关的副作用和不良反应.精准医学是一门精准医学.氨酸甲基转移酶是 thiopurine 的一种转移酶.

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