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使用消毒巾片从硬和软表面移除和禁用人类冠状病毒替代品
Runan Yan1, Angela Fraser1, Xiuping Jiang1
1Department of Food, Nutrition, and Packaging Sciences, Clemson University, Clemson, South Carolina, USA.
Applied and environmental microbiology
|September 8, 2025
概括
消毒抹布通过物理去除和化学失活,有效地减少病毒污染. 过氧化和四级化合物都能在一分钟内在表面上清除显著较低的病毒载荷.
科学领域:
- 微生物学和病毒学
- 表面科学和消毒 消毒
- 公共卫生和流行病学
背景情况:
- 像SARS-CoV-2这样的呼吸道病毒的表面污染在各种环境中具有显著的传播风险.
- 关于物理去除与消毒巾片化学失活的机制的了解有限.
- 评估对SARS-CoV-2替代品的擦拭疗效对于通知消毒协议至关重要.
研究的目的:
- 为了比较物理去除和化学失活对湿巾整体消毒功效的贡献.
- 评估基于过氧化 (H2O2) 和基于四级化合物 (QAC) 的消毒抹布对冠状病毒的有效性.
- 为了评估不同类型的表面 (玻璃和乙烯基) 上的病毒减少,并比较手动与机械擦拭.
主要方法:
- 在5%的土壤负载下,玻璃和乙烯基优惠券被SARS-CoV-2替代品 (牛冠状病毒或人类冠状病毒OC43) 污染.
- 使用手动或机械方法,使用空白,基于H2O2或QAC的擦拭器擦拭优惠券,遵循EPA协议.
- 通过超声波检测和使用TCID50试验进行量化检测的病毒恢复是在1分钟暴露和中和后进行的.
主要成果:
- 空纸巾将更多的病毒从玻璃中转移到玻璃上,而不是乙烯基,在玻璃表面留下的残留病毒较少.
- 基于H2O2和QAC的消毒抹布均将病毒标量降低了超过3 log10 TCID50/表面.
- 在手擦和机械擦之间没有观察到病毒减少的显著差异.
结论:
- 消毒巾显著减少了冠状病毒的污染和交叉污染的风险,通过物理去除和化学失活的结合.
- 物理去除病毒在硬,无孔的表面上更有效,比如玻璃,而不是更软,无孔的表面,如乙烯基.
- 标准的擦拭程序,无论是手动还是机械,都在减少病毒载荷方面始终有效.
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