血中介质素22预测了早期糖尿病病的进展
Beatriz Fernandez-Fernandez1,2,3, Takehiro Hasegawa4, Yuko Saruta5
1Departamento de Nefrología e Hipertensión, IIS-Fundación Jiménez Díaz UAM, Madrid, Spain.
American journal of nephrology
|September 8, 2025
概括
血IL-22和TNF-α水平可以识别患有早期糖尿病病的患者,他们面临慢性病进展的高风险. 这些细胞因子可能有助于预测功能恶化,尽管目前的治疗方法.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 免疫学 免疫学 免疫学
- 生物标志物发现发现
背景情况:
- 糖尿病病 (DKD) 患者面临慢性病 (CKD) 进展的高残留风险,即使服用保护药物.
- 目前的治疗方法不能完全缓解DKD进展的风险.
研究的目的:
- 调查血和尿液中细胞因子水平是否可以预测DKD患者中CKD进展的残留风险.
- 确定特定的生物标志物,以便早期检测高风险个体.
主要方法:
- 根据临床指导方针治疗的93例DKD患者的前性研究.
- 评估了16种血和10种尿液中的细胞因子水平.
- 在进展者和非进展者之间,以及在DKD患者和健康对照者之间比较细胞因子水平.
主要成果:
- 在DKD患者和对照人群中,有12种血和7种尿路细胞因子在DKD患者和对照人群之间存在差异.
- 从早期CKD (G1-G2) 进展到晚期CKD (G3-G5) 的患者血中介质素-22 (IL-22) 和瘤缩因子-α (TNF-α) 的水平较高.
- 血IL-22和TNF-α水平预测了早期CKD患者的进展,准确度高 (AUC为0.76-0.77),并与较低的GFR和较高的KDIGO风险类别相关.
结论:
- 血IL-22和TNF-α是潜在的生物标志物,可用于识别患有CKD进展高风险的早期DKD患者.
- 这些细胞因子水平可能有助于指导DKD患者的治疗决定.
- 细胞因子调节失调似乎在DKD中先于CKD进展.
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