治疗结果和Clostridioides difficile感染的严重程度和死亡率的风险因素:泰国的单中心研究
Thamonwan Chaemprida1, Worapong Nasomsong2
1Department of Internal Medicine, Phramongkutklao Hospital, Bangkok 10400, Thailand.
Journal of infection in developing countries
|September 8, 2025
概括
困难菌感染 (CDI) 具有重大风险,严重病例的死亡率很高. 慢性病是严重CDI的关键风险因素,而ICU入院和卡巴胺暴露增加了死亡风险.
科学领域:
- 传染性疾病 传染性疾病
- 流行病学 流行病学
- 临床医学 临床医学
背景情况:
- 艰难菌感染 (CDI) 是医院获得的腹的主要原因,结果不佳.
- 了解CDI严重性和死亡率因素对于有效管理至关重要.
研究的目的:
- 为了调查Clostridioides difficile感染治疗结果.
- 在泰国大学医院确定影响CDI严重程度和30天死亡率的因素.
主要方法:
- 从2019年6月到2021年12月进行的回顾性研究.
- 用单变量和多变量Cox回归分析治疗结果,严重的CDI和30天死亡率.
主要成果:
- 在187名患者中,44.2%患有严重的CDI,30天死亡率为24.1%.
- 严重的CDI死亡率明显高 (36.9%) 与非严重 (13.6%) 相比.
- 严重CDI的独立风险因素包括慢性病 (aOR 15.16). 接受ICU治疗 (aOR 3.56) 和暴露于卡巴胺 (aOR 2.79) 与30天死亡率有关.
结论:
- 在严重的CDI病例中观察到高死亡率和耐药/复发性感染.
- 慢性病是严重的CDI的一个独立风险因素.
- 接受ICU治疗和暴露于卡巴胺是所有原因的30天死亡率的独立风险因素.
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