第二和第三季度的规范性血清皮质醇水平及其相关因素:斯里兰卡的一项前性队列研究
Ishani Menike1, Shashanka Rajapakse2,3, Gayani Amarasinghe4
1District General Hospital Nuwaraeliya, Nuwara Eliya, Sri Lanka.
PloS one
|September 8, 2025
概括
斯里兰卡农村孕妇的血清皮质醇水平一般较低,但随着妊娠年龄的增加而增加. 诸如第一次怀孕,流产史和BMI等因素影响了皮质醇,但心理因素没有.
科学领域:
- 内分泌学 在内分泌学.
- 生殖健康 生殖健康
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 血清皮质醇水平是怀孕期间母亲生理适应的关键指标.
- 了解规范性皮质醇水平和影响因素对于监测怀孕健康至关重要.
研究的目的:
- 在怀孕25-29周之间建立规范性血清皮质醇水平.
- 调查母体,心理和社会因素与第二和第三个三个月的血清皮质醇水平之间的关联.
主要方法:
- 评估了斯里兰卡1010名孕妇的队列 (拉贾拉塔孕妇队列).
- 禁食早晨血清皮质醇水平测量在妊娠年龄25-29周之间.
- 通过问卷收集有关母亲人口统计,病史和心理因素 (EPDS) 的数据.
主要成果:
- 平均血清皮质醇水平为10.93μg/dL,随着妊娠年龄的提高,水平增加 (p=0.049).
- 怀孕前期,流产史,怀孕前的BMI类别和妊娠年龄独立地与较高的血清皮质醇有关.
- 在心理因素 (EPDS评分>9) 和血清皮质醇水平 (p=0.633) 之间没有发现显著的关联.
结论:
- 斯里兰卡农村的孕妇平均血清皮质醇水平较低,随着妊娠的进展而上升.
- 孕妇的特征,如初怀孕,流产史,BMI和妊娠年龄是血清皮质醇的关键决定因素.
- 通过EPDS评估的心理幸福感似乎没有影响该队列的血清皮质醇水平.
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