皮诺雷醇增强了人类口腔细胞单层中口腔屏障的完整性和功能
Soo-Bin Shin1,2, Young-Min Kim2, Ha-Young Park1
1Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup, Republic of Korea.
PloS one
|September 8, 2025
概括
皮诺雷西诺尔是一种天然化合物,通过降低透性和增加电阻来增强口腔上皮质屏障. 它还增强了维护屏障完整性的关键蛋白质,可能预防口腔疾病.
科学领域:
- 口腔生物学 口腔生物学
- 细胞生物学 细胞生物学
- 生物化学 生物化学
背景情况:
- 口腔上皮质屏障对口腔健康至关重要,可以防止病原体和压力.
- 这个屏障的破坏与牙炎和牙周炎等口腔疾病有关.
- 皮诺雷辛醇具有有益的特性,但其对口腔屏障功能的影响尚不清楚.
研究的目的:
- 调查皮诺雷西诺的潜力,以提高口腔上皮质屏障的完整性.
- 要确定pinoresinol是否影响屏障透性和电阻.
- 为了检查pinoresinol对紧结蛋白表达的影响.
主要方法:
- 使用了TR146口腔上皮细胞单层.
- 测量了明显的透性和横体电阻.
- 紧结蛋白 (occludin,MarvelD3,claudins) 的表达和局部化通过qPCR,西斑和免疫光分析.
主要成果:
- 皮诺雷醇治疗显著降低了表面的透性.
- 皮诺雷西诺醇显著增加了横体电阻.
- 皮诺雷西诺上调了奥克卢丁,MarvelD3,Claudin-1和Claudin-3的mRNA和蛋白质水平,增强了它们的局部化.
结论:
- 皮诺雷西诺尔增强了口腔上皮质屏障的功能.
- 皮诺雷西诺可以作为一种治疗剂,以预防口腔屏障功能障碍和相关疾病.
更多相关视频
08:42Author Spotlight: In Vitro Co-Culture System of Pine Shoots and Pinewood Nematode for Studying Host Volatile Response
Published on: September 27, 2024
1.2K
10:31A Liposome Membrane Permeability Assay for Investigating the Effects of Phosphatidylinositol Phosphate Groups on Membranotropic Action of Venom PLA2
Published on: September 26, 2025
492
相关概念视频
Assembly of the Lipid Bilayer in the ER
4.0K
Biological membranes are more than just a barrier separating cell cytoplasm from the outside environment. They are highly dynamic and help maintain the integrity and physiological stability of the cells as well as membrane-bound organelles. Membranes also play vital roles in cell-to-cell and intracellular communication.
A large chunk of any biological membrane is composed of phospholipids. These lipids have a heterogeneous distribution across different subcellular organelles and even between...
A large chunk of any biological membrane is composed of phospholipids. These lipids have a heterogeneous distribution across different subcellular organelles and even between...
4.0K
Preparation of Diols and Pinacol Rearrangement
4.1K
Compounds bearing two hydroxyl groups are known as diols. When the hydroxyl groups are located on adjacent carbon atoms, the diols are called vicinal diols or glycols. Under acidic conditions, vicinal diols undergo a specific reaction called pinacol rearrangement.
The reaction begins with transferring a proton from the acid catalyst to one of the hydroxyl groups, producing an oxonium ion.
The reaction begins with transferring a proton from the acid catalyst to one of the hydroxyl groups, producing an oxonium ion.
4.1K
