作为临床稳定慢性阻塞性肺病生物标志物的中性粒细胞与淋巴细胞的比率:SPIROMICS队列
Daniel T Hoesterey1, Hong Dang2, Daniela Markovic3
1University of Washington, Seattle, Washington.
Annals of the American Thoracic Society
|September 8, 2025
概括
中性粒细胞与淋巴细胞的比率 (NLR) 是慢性阻塞性肺病 (COPD) 中的一个关键炎症标志物. 升高的NLR表明COPD患者患恶化和死亡的风险更高.
科学领域:
- 肺部医学 肺部医学
- 炎症研究 炎症研究
- 生物标志物发现发现
背景情况:
- 炎症在COPD的发病过程中至关重要,但在预后模型中通常代表性不足.
- 中性粒细胞与淋巴细胞的比率 (NLR) 是一种可访问的炎症生物标志物.
研究的目的:
- 调查NLR,吸烟状态,COPD临床特征和不良结果之间的关联.
- 评估NLR的稳定性及其与其他生物标志物和吸烟的关系.
主要方法:
- 从SPIROMICS队列中的吸烟者和非吸烟者的全血细胞计数分析NLR.
- 评估NLR稳定性,与血液生物标志物的关联以及吸烟的影响.
- 按NLR四分位数进行分层,以比较临床特征,恶化和死亡率.
主要成果:
- 较高的NLR四分位数与更严重的COPD临床特征相关.
- 在6周和1年内,NLR显示可重复性.
- 较高的NLR (>3.11) 与1年恶化风险和死亡率的增加有关.
结论:
- 稳定的COPD中高的NLR作为恶化和死亡风险的预后生物标志物.
- 吸烟对NLR的影响取决于COPD的严重程度.
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