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多尺度工程异质凝复合材料用于数字光处理3D打印3D打印

Yuang Zhang1, Ryan Davis2, Saptarshi Biswas2

  • 1Department of Materials Science and Engineering, College of Engineering, Texas A&M University, College Station, Texas 77843, United States.

ACS applied materials & interfaces
|September 8, 2025
PubMed
概括
此摘要是机器生成的。

本研究介绍了一种使用微凝在聚合物矩阵中的新型生物墨水平台,用于数字光处理 (DLP) 3D打印. 这种异质的水凝复合材料为先进的组织工程应用提供了可调整的多个尺度的机械性能.

关键词:
生物材料是一种生物材料.数字光处理 (DLP) 3D打印 3D打印在水凝复合材料中.微凝是一种微凝.再生医学是一种再生医学.

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科学领域:

  • 生物材料工程 生物材料工程
  • 组织工程是组织工程.
  • 在3D生物打印中使用3D生物打印

背景情况:

  • 水凝生物墨水对于数字光处理 (DLP) 3D打印至关重要,特别是在组织再生的生物医学应用中.
  • 目前的水凝具有有限的机械性能可调性,限制其在模拟复杂组织环境中的使用.
  • 现有的调液凝机制的方法,如交叉连接或包装密度,提供了不够的控制.

研究的目的:

  • 为DLP3D打印开发一种具有多尺度异质性的新型生物墨水平台.
  • 通过将微凝纳入聚合物矩阵来制造机械调节的异质水凝复合材料.
  • 为了实现精确控制机械和生物化学特性在纳米,微和宏尺度的先进的生物医学应用.

主要方法:

  • 使用高通量微流体装置制造单分散凝甲基烯基 (GelMA) 微凝.
  • 通过聚合物度或交叉链密度调整微凝的刚度.
  • 在连续的GelMA矩阵中嵌入先前交联的微凝,以形成用于DLP打印的异质水凝复合物.

主要成果:

  • 通过调整微凝体积和打印参数,通过调整微凝体积和打印参数,达到29至244kPa的可调整复合压缩模量.
  • 通过复合材料组件的化学和物理定制,对纳米,微型和宏观尺度的特性进行证明的控制.
  • 通过使用开发的生物油墨平台,成功制造出具有宏观异质性的复杂3D结构.

结论:

  • 开发的异质水凝复合材料平台为设计用于DLP3D打印的可调节生物材料提供了独特的方法.
  • 这种模块化平台可以创建复杂的3D结构,其属性模仿本地组织和器官的复杂性.
  • 该平台具有很大的潜力,可以促进组织再生和其他需要精确控制材料特性的生物医学应用.