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Updated: Jan 18, 2026

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
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这种lncRNA ELDR通过干扰DNA复制和染色质可访问性来抑制AML的瘤性

Kaifee Arman1, Julie Ross1, Eva-Maria Piskor1,2

  • 1Institut de recherches cliniques de Montréal, McGill University, Montréal, QC, Canada.

Blood advances
|September 8, 2025
PubMed
概括

这项研究揭示了长非编码RNAELDR通过破坏DNA复制和中心转录来阻碍MLL-rAML的白血病进展. 过度表达ELDR可以提高治疗效果,减少白血病的发展,提供新的治疗途径.

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