氧化毒性与短时间的氧化使用和单边牛眼黄斑症
Marko M Popovic1,2,3, SriniVas R Sadda2
1Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada.
Retinal cases & brief reports
|September 8, 2025
概括
本案例报告详细介绍了一位患有类风湿性关节炎的患者罕见的单边牛眼黄斑病例,可能与氧化 (HCQ) 使用有关. 眼部查至关重要,尽管低剂量的HCQ视网膜毒性仍然不常见.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜成像 视网膜成像
- 药物监督 药物监督 药物监督
背景情况:
- 牛眼黄斑病是一种视网膜疾病,其特点是特定的损伤模式.
- 氧化 (HCQ) 是一种用于治疗诸如类风湿性关节炎等自身免疫性疾病的药物.
- 虽然HCQ可以引起视网膜毒性,但它通常与更高的剂量和更长的使用时间有关.
研究的目的:
- 为了记录一个患有单边牛眼巨眼病的患者的多式成像发现.
- 为了调查牛眼巨病与之前短期低剂量氧化使用之间的潜在关联.
主要方法:
- 一个77岁的女性患者的回顾性图表审查.
- 视力敏度的详细检查,眼病史和多式成像 (OCT, fundus自光) 的详细检查.
- 五年随访,以评估疾病的进展.
主要成果:
- 这位患者一只眼睛的视力下降,有风湿性关节炎病史,在20年前接受过HCQ治疗.
- 多式成像揭示了受影响眼睛的经典牛眼黄斑病变模式 (偏缩,特定的自变化).
- 另一只眼睛只显示了微妙的视网膜色素上皮质变化,并且这种情况在五年内保持稳定.
结论:
- 单边牛眼巨病症即使在短期低剂量氧化暴露后也可能发生,尽管这种情况很少见.
- 眼部查对于服用氧化的患者至关重要.
- 临床医生应考虑对牛眼黄斑病的广泛差异诊断.
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