De-MSI:一种基于深度学习的数据否定方法,通过利用化学事先的知识来增强质谱成像.
Lei Guo1,2, Chengyi Xie2, Xin Diao2
1Interdisciplinary Institute for Medical Engineering, Fuzhou University, Fuzhou 350108, China.
Analytical chemistry
|September 8, 2025
概括
我们开发了De-MSI,这是一种深度学习方法,可以在不需要地面真相的情况下消除质谱成像 (MSI) 数据. 这种新的方法提高了MSI数据质量,以便更好地进行生物样本分析.
科学领域:
- 生物医学成像学 生物医学成像学
- 计算生物学是一种计算生物学.
- 分析化学是一种分析化学.
背景情况:
- 质谱成像 (MSI) 可视化了生物样本中的离子分布.
- 数据否认提高了MSI质量,但由于复杂的噪音和缺乏基本真相而面临挑战.
- 现有的拒绝方法与固有的MSI数据复杂性作斗争.
研究的目的:
- 介绍De-MSI,这是一种用于MSI数据的新型深度学习方法,没有基本真相.
- 提高MSI数据的质量,以改善生物样本分析.
- 为实验性降噪方法提供可靠的计算替代方案.
主要方法:
- 开发了De-MSI,这是一种用于MSI的深度学习模型.
- 从杂的MSI数据中利用先前的质谱学知识来创建训练数据集.
- 训练了一个深度神经网络以消除噪音和提高图像质量.
主要成果:
- 在MALDI获得的小鼠胎儿数据的视觉检查中,De-MSI表现出卓越的性能.
- 在离子图像中获得了18.93的平均PSNR和0.74的SSIM.
- 成功增强了高分辨率 (5微米) 的小鼠大脑MSI数据和鼠大脑DESI数据.
结论:
- De-MSI有效地拒绝了MSI数据,而不要求基本真相.
- 该方法在不同的电离技术 (MALDI,DESI) 和样本类型中显示了适应性.
- De-MSI是有效分析和解释MSI数据的一个有前途的工具.
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