患有双相情感障碍的患者的生活质量:对比研究的系统审查和元分析
Yu-Cheng Wang1, Yi-Ran Huang1, Yue-Ying Wang1
1Unit of Psychiatry, Department of Public Health and Medicinal Administration, & Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macao SAR, China.
Journal of affective disorders
|September 8, 2025
概括
生命质量 (QoL) 在所有领域都显著受损于euthymic双极障碍 (BD) 患者. 干预措施应解决残留症状和心理社会因素,以改善BD患者的QOL结果.
科学领域:
- 精神病学和心理健康 精神病学和心理健康
- 生活质量研究 研究 生命质量研究
- 系统性审查和元分析
背景情况:
- 双极性障碍 (BD) 是一种慢性疾病,对生活质量 (QoL) 有重大影响.
- 之前对优异性BD患者的QoL的研究产生了不一致的结果.
- 这项研究系统地审查和元分析了euthymic BD患者与健康对照者的QoL.
研究的目的:
- 量化QoL损伤在euthymicBD患者在各种领域.
- 为了比较euthymicBD患者和健康对照之间的QoL.
- 为了确定影响QoL差异的潜在调节者.
主要方法:
- 在国际和中国数据库中进行了全面的文献搜索.
- 包含了对比性研究,评估euthymic BD患者和健康对照者的QoL.
- 使用随机效应建模的标准化平均差异 (SMD) 并执行子组/元回归分析.
主要成果:
- 分析了27项研究,涉及2055名心脏病患者和3576名健康对照.
- 与对照人群相比,在所有领域中发现了优化性BD患者的显著QOL损伤.
- 在身体和社会关系领域 (WHOQOL) 发现了最大的损害;较大的样本大小与较小的差异相关.
结论:
- 持续的QoL损伤在所有评估领域的euthymicBD患者中是明显的.
- 强调需要针对残留症状,并发症和心理社会因素的综合干预措施.
- 强调需要改善BD患者群体的QOL结果.
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