早期心房和的全球负担:基于人口的研究
Yifan Lu1, Yu Liu2, Yuji Zhang2
1Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK.
International journal of cardiology
|September 8, 2025
概括
自1990年以来,早发性心房和 (AF/AFL) 的全球负担显著增加,主要原因是人口增长和高静脉压. 这凸显了针对年龄的具体策略的必要性,以解决这个日益增长的心血管健康问题.
科学领域:
- 心脏病学 心脏病学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 心房动和动 (AF/AFL) 通常与衰老有关.
- 早期发病的AF/AFL (<65岁) 越来越被认为是心肌病的潜在指标.
- 早期发病的AF/AFL的全球负担仍然不太清楚.
研究的目的:
- 从1990年到2021年,分析早期AF/AFL的流行,发病率和负担的全球趋势.
- 确定导致早期发作的AF/AFL增加的关键驱动因素.
- 根据AF/AFL和心肌病的同时发生模式对国家进行分类.
主要方法:
- 利用了2011年全球疾病负担研究对30-64岁的个体的数据.
- 分析了流行,发病率,残疾调整寿命年 (DALYs) 和死亡率的趋势.
- 雇佣了达斯·古普塔的分解和空间共发生分析与心肌病和心肌炎 (CMP).
主要成果:
- 在1990年至2021年期间,早期发作的AF/AFL的年龄标准化流行率,发病率和DALY率显著增加 (AAPC:0.14%,0.11%,0.07%)
- 人口增长占早期发病病例增加的89%,其次是老龄化 (17%) 和年龄特定患病率上升 (7%).
- 高静脉血压是主要的危险因素,每10万人口贡献13.04个DALY.
结论:
- 在过去的三十年中,早期发病的AF/AFL的全球负担显著增加,与老年人群的稳定趋势不同.
- 人口增长和高静脉压是这种增长的主要驱动因素.
- 研究结果强调需要针对年龄特定的策略和针对早期发病的AF/AFL进行有针对性的研究,考虑到其与心肌病的联系.
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