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用β-环氧化装饰的甲酸涂层的SPION用于改善temozolomide的输送

Martyna Kasprzyk¹, Alicja Hinz², Gabriela Opiła³

¹Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, Kraków 30-387, Poland; Doctoral School of Exact and Natural Sciences, Jagiellonian University, Prof. S. Łojasiewicza 11, Kraków 30-348, Poland.

International journal of pharmaceutics

|September 8, 2025

概括

使用超偏磁性氧化铁纳米粒子 (SPION) 的新型药物输送系统增强了对质母细胞瘤的temozolomide (TMZ) 治疗. 这种有针对性的方法提高了药物的稳定性,减少了副作用,并提供了MRI成像功能.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
在瘤学瘤学.

背景情况:

泰莫佐洛米德 (Temozolomide,简称TMZ) 是一种标准的质母细胞瘤治疗方法,但其稳定性较差,并具有显著的副作用.
有效和有针对性的药物输送系统对于改善质母细胞瘤治疗至关重要.
超偏磁铁氧化物纳米粒子 (SPION) 提供了针对药物输送和成像的潜力.

研究的目的:

开发一种基于SPION的新型药物输送系统,用于针对性地向质母细胞瘤细胞输送temozolomide (TMZ).
为了提高TMZ的稳定性和有效性,同时最大限度地降低系统性毒性.
调查SPIONs在联合治疗和磁共振成像 (MRI) 指导方面的潜力.

主要方法:

为了稳定和向CD44受体,SPIONs被合成并涂上氨酸.
泰莫佐洛米德 (TMZ) 通过beta-cyclodextrin复合装载到SPIONs上,以控制释放.
在体外研究中评估了药物释放动力学,溶血活性,细胞毒性 (hPBMC,质母细胞细胞) 和抗癌作用 (细胞循环停止,增殖抑制).

主要成果:

开发的系统在生理条件下在48小时内证明了TMZ的受控,持续释放.
该SPION-氨酸-TMZ系统没有表现出血液溶解活性或对正常人体外围血液单核细胞 (hPBMC) 的毒性.
装有TMZ的SPIONs被质母细胞细胞有效地内化,诱导DNA损伤,细胞循环停止和增殖抑制,而不会伤害正常细胞.

结论:

开发的基于SPION的药物递送系统为球母细胞瘤向治疗提供了一个有前途的平台,增强了TMZ的疗效和安全性.
该系统的磁性特性使其在MRI成像和磁场引导治疗中具有潜在的应用.
这种纳米技术驱动的方法代表了克服传统temozolomide治疗质母细胞瘤的局限性的重大进步.

关键词:

药物输送是药物输送的过程.质母细胞瘤 (glioblastoma) 是一个核磁共振成像 (MRI) 的成像磁性纳米粒子是一种磁性纳米粒子.泰莫佐洛米德 (Temozolomide) 是一种可怕的药物.

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