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剂量,剂量速率和分剂量会影响光子FLASH辐射后的小鼠皮肤反应

Kathryn H Brown¹, Mihaela Ghita-Pettigrew¹, Malachy P McIvor¹

¹Patrick G. Johnston Centre for Cancer Research, Queen's University Belfast, Northern Ireland, UK.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

|September 8, 2025

概括

光子FLASH放射治疗 (FLASH-RT) 显示出正常组织节约的潜力,类似于质子和电子束. 这项研究证实了使用光子的可行性,剂量和剂量率是影响放射生物反应的关键因素.

科学领域:

辐射瘤学辐射瘤学
临床前研究临床前研究
医学物理医学物理

背景情况:

与传统 (CONV) 暴露相比,FLASH辐射疗法 (FLASH-RT) 使用超高剂量率来节省正常组织.
大多数FLASH-RT研究都使用了电子和质子,对光子FLASH反应的研究有限.
鉴于光子的广泛临床使用,描述光子FLASH效应至关重要.

研究的目的:

通过使用新型光子FLASH系统 (FLASH-SARRP) 研究剂量,剂量速率和分剂量对小鼠皮肤毒性的影响.
在黑色素瘤异种移植模型中,将光子FLASH-RT与CONV暴露的疗效进行比较.

主要方法:

在C57BL/6小鼠中,在CONV (3.2 Gy/min) 和FLASH (72 Gy/s) 剂量速率下评估了皮肤毒性.
放射后8-12周进行了组织病理学分析和视觉评分.
使用B16-F10黑色素瘤异种移植模型评估了瘤生长延迟.

主要成果:

与CONV暴露相比,FLASH暴露延迟了皮肤毒性,并减少了增生和纤维化 (p < 0.01).
在FLASH-RT中观察到剂量依赖的节约效应,但分剂量暴露减少了这种节约.
光子FLASH-RT证明了与CONV暴露 (p = 0.99) 相比的瘤控制疗效.

结论:

光子FLASH-RT是可行的,并且实现了与质子和电子FLASH-RT相比的正常组织节约.
调节对光子FLASH的放射生物反应的关键参数包括剂量,平均剂量速率和束结构.

关键词:

一个闪光灯.光子光子是一个光子.临床前临床前皮肤皮肤皮肤皮肤有毒性有毒性

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