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Updated: Aug 1, 2026

Generating iPS Cells from MEFS through Forced Expression of Sox-2, Oct-4, c-Myc, and Klf4
13:02

Generating iPS Cells from MEFS through Forced Expression of Sox-2, Oct-4, c-Myc, and Klf4

Published on: April 7, 2008

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通过使用合成RNA,MDM4能够从PBMC中有效地产生人类iPS细胞

Masato Nakagawa1,2, Mizuho Nogi3, Hatsuki Doi3

  • 1Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, 606-8507, Japan. nakagawa@cira.kyoto-u.ac.jp.

Scientific reports
|September 8, 2025
PubMed
概括

现在可以使用合成RNA从外围血液单核细胞 (PBMC) 生成诱导多能干细胞 (iPS细胞). 这项研究发现,通过MDM4抑制p53可以提高从PBMCs的iPS细胞重编程效率.

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Generation of Human Induced Pluripotent Stem Cells from Peripheral Blood Using the STEMCCA Lentiviral Vector

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RNA-based Reprogramming of Human Primary Fibroblasts into Induced Pluripotent Stem Cells

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Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...