测试剂量对急性过敏反应的发展的影响
Dennis Marjoncu1, Kori Holman2
1Methodist Le Bonheur Healthcare, Department of Pharmacy, Memphis, TN, USA. dennis.marjoncu@mlh.org.
概括
布莱米辛的测试剂量没有预测过敏反应. 虽然测试剂量没有发生反应,但在接受测试剂量的患者中观察到过敏症的数值发病率较高,尽管在统计学上并不显著.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 过敏反应是白胺化疗的已知副作用.
- 测试剂量有时用于预测过敏症,但缺乏可靠的支持数据.
研究的目的:
- 为了比较接受测试剂量的患者与未接受测试剂量的患者中,白素过敏反应的发生率.
主要方法:
- 对77名接受白血素治疗的患者进行了回顾性分析.
- 根据患者是否在服用完整剂量之前接受了白色胺素试剂量,患者被划分为组.
- 通过紧急药物或提供者笔记的医疗记录文档识别过敏.
主要成果:
- 在服用84个试验剂量期间,没有报告过敏反应.
- 测试剂量组的3名患者 (5.5%) 经历过敏反应与全剂量白胺剂量,相比之下,在没有测试剂量组的零.
- 观察到的两组反应速率的差异在统计学上并不显著 (p=0.264).
结论:
- 阴性白素测试剂量与缺乏急性过敏反应没有相关性.
- 在接受测试剂量的患者中,注意到过敏反应的数值发病率较高,这需要进一步调查.
- 需要进行更大规模的研究来验证这些关于白胺测试剂量和过敏性的发现.
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