骨折风险评估工具的预测能力:系统审查的概述
Griselda-Adriana Cruz-Priego1,2,3, Berenice Araiza-Nava1,2, Lucía Méndez-Sánchez1,2,3
1Clinical Epidemiology Research Unit, Hospital Infantil de Mexico "Federico Gomez", Mexico City, Mexico.
概括
这次审查发现了26种骨折风险预测工具,大多数的性能中等 (AUC为0.7-0.75). 性能差异很大,突出了需要考虑工具的特点,准确的断裂预测.
科学领域:
- 骨质疏松症的研究研究.
- 临床流行病学临床流行病学
- 生物统计学 生物统计学
背景情况:
- 骨折风险预测工具对于骨质疏松症管理至关重要.
- 现有的工具在复杂性和预测性能方面差异很大.
- 需要对当前工具进行全面的概述.
研究的目的:
- 系统地审查和概述关于骨折风险预测工具的现有系统审查.
- 评估各种骨折风险评估工具的预测能力和性能指标.
主要方法:
- 包括评估骨折风险工具预测能力的系统审查.
- 主要结果:从接收器运行特征 (ROC) 分析得出的曲线下的面积 (AUC).
- 专注于针对一般成年人群 (男性和女性) 的工具.
主要成果:
- 确定了26种不同的骨折风险预测工具,最多有21,717个变量.
- 观察到广泛的预测性能 (AUC 0.58-0.90),大多数工具在0.7-0.75.5之间.
- 没有一个单一的工具始终优于其他工具;性能在不同研究中波动.
结论:
- 大多数骨折风险模型显示中等预测性表现 (AUC 0.7-0.75).
- 比较工具需要仔细考虑其设计,变量和数据.
- 诸如性别,年龄,骨折类型和预测时间框架等因素会影响临床实践中的工具实用性.
相关概念视频
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
401
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
401
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
409
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
409
01:27Fractures: Bone Repair
5.1K
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
5.1K