减少伤害厌恶与痴呆症患者的反社会行为和轨道前额缩有关
Tony X Phan1, Jayden J Lee1, Jenifer Z Siegel2
1Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|September 9, 2025
概括
痴呆症患者,特别是那些患有行为变异前性痴呆症 (bvFTD) 患者,表现出与右前极缩相关的减少伤害厌恶. 这与反社会行为和 Empathy 障碍有关.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 神经学 神经学
背景情况:
- 反社会行为在痴呆症中很常见,但其神经认知基础尚未得到充分理解.
- 腹中/轨道前皮层 (vmPFC/OFC) 参与决策和社会认知.
研究的目的:
- 在痴呆症患者中调查伤害厌恶,反社会行为和vmPFC/OFC缩之间的关系.
- 为了比较行为变体前性痴呆症 (bvFTD) 和阿尔茨海默病 (AD) 的伤害厌恶.
主要方法:
- 43名痴呆症患者 (23名bvFTD,20名AD) 完成了一项评估危害厌恶的决策任务.
- 线性回归分析了伤害厌恶,反社会行为,精神病,社会情感功能和vmPFC/OFC皮质厚度之间的关联.
主要成果:
- 与AD患者相比,bvFTD患者表现出较低的伤害厌恶.
- 减少对伤害他人的厌恶与非侵略性的反社会行为,精神病特征和同情心/视角受损相关.
- 这种减少的厌恶与右侧vmPFC/OFC的缩有关.
结论:
- 痴呆症中的伤害厌恶缺陷与右前极缩有关.
- 这些变化可能会导致痴呆症患者违规和犯罪行为.
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