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奥斯曼斯水提取物对基于有机体和器官芯片技术的DBP引起的肝功能障碍的保护作用

Qing Feng¹, Hongguo Chen², Meng Ren³

¹Key Laboratory of Environmental Related Diseases and One Health, Xianning Medical College, Hubei University of Science and Technology, Xianning 437100, China; Hubei Key Laboratory of Diabetes and Angiopathy, School of Pharmacy, Xinning Medical College, Hubei University of Science & Technology, Xianning 437100, PR China.

Food research international (Ottawa, Ont.)

|September 9, 2025

概括

奥斯曼斯芳香水提取物 (OSF) 通过减少氧化应激和脂质障碍,保护免受迪布甲 (DBP) 引起的肝损伤. 这种天然提取物显示出治疗DBP诱导的肝功能障碍的潜力.

科学领域:

毒理学毒理学毒理学
药理学药理学是指药理学的学科.
生物技术是生物技术.

背景情况:

迪布甲酸盐 (DBP) 暴露会导致严重的肝损伤.
了解防治DBP引起的肝毒性保护机制至关重要.

研究的目的:

调查奥斯曼斯芳香水提取物 (OSF) 对DBP诱导的肝损伤的保护作用.
阐明OSF的潜在保护机制.

主要方法:

利用肝脏器官和肝脏器官芯片技术来建模肝脏的微环境.
进行了代谢分析,以确定代谢变化.
进行了分子对接研究,以评估活性化合物与标的相互作用.

主要成果:

在肝脏模型中,DBP诱导了氧化应激和脂质代谢障碍.
OSF的干预显著减少了与DBP暴露相关的异常代谢物.
分子对接证实了OSF活性成分与肝脏保护相关的关键标的结合.

结论:

OSF显示出对DBP诱导的肝损伤有显著的肝保护作用.
通过减轻氧化应激和正常化脂质代谢,OSF减轻了DBP的毒性.
OSF是一种有前途的天然治疗剂,用于预防和治疗DBP诱导的肝功能障碍.

关键词:

双乙烯甲酸二甲基的使用方法进行代谢学分析.器官芯片器官芯片器官类动物器官类动物奥斯曼斯的水提取物

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