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对植物性低血糖的系统审查:生物来源,制备方法,作用机制和结构-活性关系
Tianzhu Liu1, Xiaojun Yan1, Chenhui Zhu1
1Engineering Research Center of Western Resource Innovation Medicine Green Manufacturing, Ministry of Education, School of Chemical Engineering, Northwest University, Xi'an 710069, China; Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Xi'an 710069, China; Biotech. & Biomed. Research Institute, Northwest University, Xi'an 710069, China; Shaanxi Green Bio-Manufacturing Future Industry Research Institute, Northwest University, Xi'an 710127, China.
植物性低血糖 (PDHPs) 是目前糖尿病药物更安全的替代品. 这篇评论探讨了它们的来源,准备和潜力,突出了AI.
科学领域:
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
- 自然产品 化学 化学
背景情况:
- 目前的糖尿病药物具有显著的不良影响,推动寻找更安全的替代品.
- 由于其有效性和安全性,植物性低血糖 (PDHPs) 对糖尿病管理具有前景.
- 开发新型低血糖药物是关键的全球卫生优先事项.
研究的目的:
- 综合审查植物性低血糖 (PDHPs) 的最新进展.
- 检查PDHPs的生物来源,制备,净化,结构识别,结构-活动关系和活动评估.
- 探索人工智能 (AI) 在PDHPs发展中的作用和未来前景.
主要方法:
- 对PDHPs最近研究的文献综述.
- 对涵盖生物来源,提取,净化和表征技术的研究进行分析.
- 综合关于结构-活动关系和生物活动评估的信息.
- 评估人工智能应用和PDHP研究的未来趋势.
主要成果:
- PDHPs显示出显著的低血糖活性和有利的安全性.
- 已经确定了PDHPs广泛的生物来源和制备方法.
- 结构-活性关系研究对于优化PDHP疗效至关重要.
- 人工智能为加速PDHP发现和开发提供了机会.
结论:
- PDHPs代表了一类有希望的天然化合物用于糖尿病治疗和预防.
- 需要进一步的研究,特别是人工智能辅助的研究,才能充分实现PDHPs的治疗潜力.
- 本综述为推进PDHP研究和产品开发提供了基础资源.
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