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饮食因素与口腔粘膜病变之间的因果关系:双样本孟德尔随机化分析

Siqi Jiang¹, Yi Liu², Jing Lei¹

¹Department of Stomatology, Taikang Tongji (Wuhan) Hospital, Wuhan, Hubei Province, P.R. China.

|September 9, 2025

概括

干水果的摄入可能会降低复发性口腔口炎 (RAS) 的风险,而非油性鱼的摄入可能会降低口腔平坦 (OLP) 的风险. 这些发现支持口腔粘膜病变 (OML) 的饮食指南.

科学领域:

遗传学和流行病学
营养科学营养科学
口腔医学是指口腔医学.

背景情况:

以前的研究表明饮食影响口腔粘膜病变 (OML),但研究往往缺乏强大的方法.
在先前的研究中,有限的样本大小和混因素需要进一步调查与OMLs的因果饮食联系.

研究的目的:

调查13种饮食因素和三种常见的OML之间的因果关系:复发性口腔口腔炎 (RAS),口腔平坦 (OLP) 和口腔白血病 (OLK).
利用大规模的遗传数据,对饮食-OML关联进行更可靠的评估,最大限度地减少偏差.

主要方法:

利用两个样本的门德尔随机化 (MR) 分析与公开可用的全基因组关联研究 (GWAS) 总结统计数据.
采用逆方差加权 (IVW) 作为主要方法,使用MR-Egger,加权中位数和其他方法进行验证.
进行了灵敏度分析 (MR-Egger拦截,留出一个,MR-PRESSO) 和FDR校正,以确保结果的有效性,并考虑多次测试.

主要成果:

在干果摄入量与RAS风险 (OR=0.281,P-FDR=0.004) 之间发现了显著的反向因果关系.
非油性鱼类摄入量与OLP风险有显著的反向因果关系 (OR=0.072,P-FDR=0.026).
没有检测到水平形或异质性的证据,支持发现的有效性.

结论:

干燥水果的消费可能会对RAS有保护作用.
增加非油性鱼类的摄入量可能会降低OLP的风险.
这些发现为旨在预防和管理OMLs的特定饮食建议提供了更有力的证据.

关键词:

门德尔的随机化饮食因素饮食因素干果的摄入量干果的摄入量没有每日鱼类摄入量.在口腔粘膜病变.

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