日本慢性自发性疹的流行,并发症和当前管理:回顾性索赔数据库研究
Atsushi Fukunaga1, Yuko Kishi2, Yoshinori Sunaga2
1Osaka Medical and Pharmaceutical University, Takatsuki, Osaka, Japan.
The Journal of dermatology
|September 9, 2025
概括
在日本,慢性自发性疹 (CSU) 的患病率在2021年增加到1.6%,女性患病率更高. 治疗通常涉及H1-抗组胺剂,但口服皮质类固醇也很常见,表明需要标准化的CSU护理.
科学领域:
- 皮肤病学 皮肤病学
- 流行病学 流行病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 慢性自发性疹 (CSU) 在全球影响0.5%-1.0%,但日本关于患病率,并发症和治疗的数据很少.
- 了解这些因素对于改善日本的患者管理和医疗保健资源分配至关重要.
研究的目的:
- 为了估计CSU在日本的流行和发病率.
- 确定常见的并发症和当前的治疗模式.
- 评估CSU患者的医疗保健资源利用情况.
主要方法:
- 使用JMDC索赔数据库 (日本) 的观察性研究.
- 根据ICD-10代码定义的CSU和H1-抗组胺剂在3个月内使用≥6周.
- 进行了横截面和纵向分析.
主要成果:
- CSU 的流行率从1.2% (2016) 增加到1.6% (2021),发病率稳定在0.7%-0.8%.
- 在女性中观察到更高的患病率和发病率;过敏性鼻炎/结膜炎是常见的并发症.
- ~95%的患者使用H1-抗组胺剂;口服皮质类固醇很常见,特别是在儿童中;奥马利祖马布的使用是有限的.
结论:
- 日本最近的CSU患病率为1.6%,发病率为0.8%.
- 治疗模式显示高H1-抗组胺使用,但也显著的口服皮质类固醇使用,表明次优化管理.
- 在日本,鼓励对不受控制的CSU患者进行标准化治疗实践.
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