对青素有反应的SmMPK3-SmWRKY33模块积极调节了Salvia miltiorrhiza中的坦辛生物合成
Renjun Qu1, Shiwei Wang1, Xinxin Wang1
1State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Plant biotechnology journal
|September 9, 2025
概括
贾斯蒙酸信号通过SmWRKY33转录因子和SmMPK3激酶调节Salvia miltiorrhiza中的坦辛生物合成. 这一途径增强了坦辛的产生,为代谢工程提供了目标.
科学领域:
- 植物分子生物学 植物分子生物学
- 代谢工程是代谢工程.
- 传统中国医药 传统中国医药
背景情况:
- 来自Salvia miltiorrhiza的tanshinones是治疗心血管疾病的关键.
- 贾斯莫纳酸盐 (JAs) 影响坦辛水平,但调节机制尚不清楚.
研究的目的:
- 为了阐明JA信号与Salvia miltiorrhiza中的tanshinone生物合成之间的分子联系.
- 确定参与该途径的关键监管机构.
主要方法:
- 采用了多原子分析 (转录组学,蛋白质组学) 和遗传方法.
- 研究了转录因子SmWRKY33,它的点,以及与JA信号组件的相互作用.
- 研究了SmMPK3激酶在调节SmWRKY33活性中的作用.
主要成果:
- SmWRKY33,一个JA-响应的转录因子,直接激活关键的tanshinone生物合成基因.
- SmWRKY33的活性是通过与JA抑制剂SmJAZ8.8的相互作用来调节的.
- SmMPK3可酸化SmWRKY33,增强其转录活性和DNA结合.
结论:
- 与MAPK酸化集成的JA信号,精确地控制了tanshinone生物合成.
- SmWRKY33和SmMPK3是关键的调节剂,为增强Salvia miltiorrhiza中的坦辛生产提供了目标.
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