口服抗病毒药物后肝硬度测量有效预测慢性C型肝炎患者的HCC风险
Yu Rim Lee1, Hyun Young Woo2, Young Oh Kweon3
1Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu, South Korea.
肝细胞癌 (HCC) 的风险可以预测后持续的病毒学反应 (SVR) 与直接作用的抗病毒药物 (DAA) 治疗. 在SVR后一年的肝硬度测量 (LSM) 是HCC发展的强有力的预测指标,特别是在晚期肝病中.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 病毒性肝炎病毒性肝炎
- 在瘤学瘤学.
背景情况:
- 肝细胞癌 (HCC) 仍然是一个风险,即使在持续的病毒学反应 (SVR) 直接作用的抗病毒疗法 (DAA) 慢性肝炎C.
- 需要HCC的预测模型来管理SVR后的患者.
研究的目的:
- 通过使用DAA治疗实现SVR的患者的纵向数据来识别和验证预测因素和HCC风险模型.
- 评估肝硬度测量 (LSM) 对SVR后HCC发展的预测性能.
主要方法:
- 在2778名患者的回顾性队列研究中,在DAA治疗后获得了SVR.
- 模型性能使用Harrell的C指数和时间依赖的AUROC进行评估.
- 在基线和SVR后一年的LSM的纵向评估.
主要成果:
- 154名 (5.5%) 患者在SVR后的中位数为3.3年内发展出HCC.
- 在SVR后一年的LSM与基线LSM (C指数:0.788与0.760) 相比,对HCC风险的预测性表现更好.
- 在晚期慢性肝病患者中,SVR后一年的LSM显示出强大的预测值 (C指数:0.744,3年AUROC:0.794).
结论:
- 在实现SVR一年后,肝硬度测量 (LSM) 是HCC风险的有效预测指标.
- 在DAA治疗后的晚期慢性肝病患者中,LSM对于预测HCC特别有价值.
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