巴西林通过调节炎症,氧化应激和线粒体功能障碍来减轻脏缺血-再输液损伤
Jinyi Zhao1, Lulu Zhang1,2, Fei Mu1
1Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, China.
Histology and histopathology
|September 9, 2025
概括
巴西林通过减少炎症,氧化应激和细胞死亡来防止急性损伤 (AKI). 这种天然化合物显示出作为治疗损伤的治疗剂的前景.
科学领域:
- 药理学 药理学是指药理学的学科.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 自然产品 化学 化学
背景情况:
- 巴西林是一种来自*Caesalpinia sappan*的同异黄,已知具有治疗潜力.
- 它在急性损伤 (AKI) 病原发生中的作用仍然在很大程度上未被探索.
研究的目的:
- 调查巴西林对因缺血/再输 (I/R) 引起的AKI的保护作用.
- 阐明巴西林在AKI中的作用的潜在分子机制.
主要方法:
- 小鼠经历了I/R损伤与或没有巴西林预处理.
- 评估了功能标志物 (血清肌素,BUN,LCN2) 和他的病理学.
- 细胞亡,炎症,氧化应激和线粒体功能在体内和体外 (HK-2细胞) 进行了评估.
- 分析了关键的信号通路 (TLR4/NF-κB/NLRP3,Nrf2/HO-1). 这些信号通路包括:
主要成果:
- 巴西林治疗前显著降低了血清肌素,BUN和LCN2水平.
- 它减轻了脏的组织病理损伤,亡,炎症和氧化应激.
- 巴西林抑制了TLR4/NF-κB/NLRP3通路,并激活了Nrf2/HO-1通路.
- 在体外,巴西林通过调节亡相关蛋白质和改善线粒体功能来保护HK-2细胞免受OGD/R损伤.
结论:
- 巴西林显示出对I/R诱导的AKI具有显著的保护作用.
- 它的机制包括减轻炎症,氧化应激,亡和线粒体损伤.
- 巴西林显示出作为AKI新型治疗剂的潜力.
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