瘤微环境响应TPZ载荷的核心外聚合物纳米颗粒用于选择性癌症生物减少疗法
Sajjad Alimohammadvand1, Mohammad Shahpouri1, Mohammad Amin Adili Aghdam1
1Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Advanced pharmaceutical bulletin
|September 9, 2025
概括
对低氧反应的纳米颗粒将提拉巴胺传递给乳腺癌细胞,增强药物的活性并减少瘤生长. 这种有针对性的方法克服了瘤缺氧障碍,有效治疗癌症.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 癌症治疗 癌症治疗
背景情况:
- 瘤缺氧是抗癌药物疗效的一个重大挑战.
- 开发有针对性的药物输送系统对于克服缺氧诱导的耐药性至关重要.
研究的目的:
- 设计和评估对缺氧反应的纳米颗粒 (APAP NPs) 用于针对性地向缺氧性乳腺癌提供提拉巴胺 (TPZ).
- 研究APAPNP在增强低氧瘤微环境中的药物透和活性方面的疗效.
主要方法:
- 合成金纳米颗粒 (AuNPs) 涂有聚乙烯胺 (PEI) 和一个缺氧可切割的mPEG-AZO链接器.
- 使用2D细胞培养和3D球体 (MDA-MB-231,MCF-7) 在正常和低氧条件下评估纳米粒子行为.
- 细胞毒性评估,反应性氧物种 (ROS) 生成,线粒体膜潜力,细胞亡,细胞吸收和球体破坏.
主要成果:
- APAP NPs对MDA-MB-231细胞表现出显著的细胞毒性,降低了TPZ IC50.
- 在低氧条件下观察到增强的ROS生成和减少的线粒体膜潜力.
- 实现了广泛的亡,减少了细胞粘附,增加了细胞吸收 (在缺氧下~100倍),并破坏了MCF-7球体.
结论:
- APAP@TPZ纳米粒子作为生物相容,多阶段激活平台,用于增强HAP向缺氧瘤的传递.
- 该系统通过PEG脱落和TPZ生物减少促进低氧性乳腺癌微瘤的选择性根除.
相关概念视频
The Tumor Microenvironment
7.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.6K
Tumor Immunotherapy
1.8K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.8K
Targeted Cancer Therapies
8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
8.6K


